Dental pulp stem cells pdf




















Informed consent was obtained from all participants in accordance with the Ethical Guidelines for Clinical Studies. All methods used in this study were in accordance with the Declaration of Helsinki. William Kaelin; Yan et al. A luciferase reporter vector, pGL4.

The specific primers used in this study are shown in Table 1. After washing with Tris-buffered saline containing Tween 20 0. The samples were then centrifuged at rpm for 5 min, and the supernatant was aspirated and washed four times. Pulp tissues were removed from the incisors and cultured under normoxic or hypoxic conditions for 48 h. Compound Sakura Finetek, Tokyo, Japan. Six-micrometer-thick frozen sections were prepared.

Goswami, M. Outcomes of luxation injuries to primary teeth—A systematic review. Oral Biol. PubMed Google Scholar. Rungvechvuttivittaya, S. Responses of macrophage-associated antigen-expressing cells in the dental pulp of rat molars to experimental tooth replantation. Tsukamoto-Tanaka, H. Histochemical and immunocytochemical study of hard tissue formation in dental pulp during the healing process in rat molars after tooth replantation.

Cell Tissue Res. Zhao, C. Immunohistochemical study of hard tissue formation in the rat pulp cavity after tooth replantation. Nakakura-Ohshima, K. The effect of reducing the root length by apicoectomy on dental pulp revascularization following tooth replantation in mice. Aranha, A. Hypoxia enhances the angiogenic potential of human dental pulp cells. Rombouts, C. Pulp vascularization during tooth development, regeneration, and therapy. Li, L. Hypoxia promotes mineralization of human dental pulp cells.

Ito, K. Hypoxic condition promotes differentiation and mineralization of dental pulp cells in vivo. Lee, P. Cellular adaption to hypoxia through hypoxia inducible factors and beyond. Cell Biol. Majmundar, A. Hypoxia-inducible factors and the response to hypoxic stress.

Cell 40 , — Jaakkola, P. Science , — Ratcliffe, P. Oxygen sensing and hypoxia signaling pathways in animals: The implications of physiology for cancer.

Dengler, V. Transcriptional regulation by hypoxia inducible factors. Google Scholar. Gao, S. Hypoxia-response element HRE -directed transcriptional regulation of the rat lysyl oxidase gene in response to cobalt and cadmium. Suda, T. Metabolic regulation of hematopoietic stem cells in the hypoxic niche. Cell Stem Cell 9 , — Hurwitz, S. Hematopoietic stem and progenitor cell signaling in the niche. Leukemia 34 , — Rey, S. Hypoxia-inducible factordependent mechanisms of vascularization and vascular remodeling.

Devignes, C. HIF signaling in osteoblast-lineage cells promotes systemic breast cancer growth and metastasis in mice. Wang, H. Cellular hypoxia promotes heterotopic ossification by amplifying BMP signaling.

Bone Miner. Fortier LA. Stem cells: classifications, controversies, and clinical V, Haapasalo M. Deciduous and permanent dental pulp mesenchy- applications.

Vet Surg ;— Human embryonic stem cells. J Endod ;— J Cell Sci ;— Dental pulp cells 5. Gardner RL. Stem cells: potency, plasticity and public perception. Dev Biol 6. Osteoprogenitor cells within J Orthop Res ;— Shi S.

Immunomodulatory properties of stem cells from human 7. Gage FH. Mammalian neural stem cells. Science ;—8. Stem Cell Res Ther ; Gimble J, Guilak F. Adipose-derived adult stem cells: isolation, Smith AJ, Lesot H.

Induction and regulation of crown dentinogen- characterization, and differentiation potential. Cytotherapy ;5: esis: embryonic events as a template for dental tissue repair?

Crit —9. Rev Oral Biol Med ;— Separation of human epidermal stem cells Transden- from transit amplifying cells on the basis of differences in integrin tinal stimulation of tertiary dentinogenesis. Adv Dent Res ; function and expression. Cell ;— Postnatal Proc DJ. J Bone Miner Res ;— Odontoblast differentiation.

Int SHED: stem cells from human exfoliated deciduous teeth. Proc J Dev Biol ;— Angiogenic growth factors in human Arch Oral Biol ;—6. Investigation of multipotent Tziafas D. Basic mechanisms of cytodifferentiation and dentino- postnatal stem cells from human periodontal ligament.

Lancet genesis during dental pulp repair. Int J Dev Biol ;— The Mesenchymal stem cell- matrix components. Biomaterials ;— PLoS One Autoradiographic analysis ;1:e Arch Oral Biol ;— Characterization of the apical papilla and its residing stem cells J Endod Reactionary dentinogenesis.

Saving pulps: a biological basis. An overview. Mesenchymal stem cells derived Prim Dent Care ;—6. Nakashima M. Induction of dentine in amputated pulp of dogs by role in regenerative medicine. J Dent Res ;— Odontogenic collagen matrix. Arch Oral Biol ;—9. Induc- cells. Biol Cell ;— Tissue engineering of complex tooth structures on biodegradable Nucleation of apatite crystals in polymer scaffolds. Nat Mater ;2: Stem-cell-based —8. Dental pulp tissue engineering with stem cells is facilitated by interaction between self-assembled dentin matrix from exfoliated deciduous teeth.

J Endod ;—9. SHED differentiate into functional odontoblasts and J Dent Res ;—6. Bone sialoprotein-induced reparative dentinogenesis in the Clin Oral Investig ;—9. Effects of morphogen and Osteogenic scaffold porogen on the differentiation of dental pulp stem cells.

J proteins bone sialoprotein and bone morphogenetic protein-7 and Endod ;— J Mater Sci Mater Med ;— Bone morphogenetic proteins in dentin regenera- Dentin-derived BMP-2 and odontoblast differentiation. J Dent tion for potential use in endodontic therapy.

Cytokine Growth Res ;—8. Factor Rev ;— J Biomed Mater Res A. Bone regeneration by human dental pulp stem cells using a helioxanthin derivative and cell-sheet technology. Bone healing by sterilizable calcium phosphate tetrapods eluting osteogenic molecules. Enhancement of bone formation ex vivo and in vivo by a helioxanthin-derivative. Biochem Biophys Res Commun. A novel osteogenic helioxanthin-derivative acts in a BMP-dependent manner.

Eur Cell Mater. Reconstruction of large cranial defects in nonimmunosuppressed experimental design with human dental pulp stem cells. J Craniofac Surg. Osteogenic differentiation of stem cells derived from human periodontal ligaments and pulp of human exfoliated deciduous teeth. Cell Tissue Res. Dental stem cells and their applications in dental tissue engineering.

Open Dent J. Bioengineered teeth from cultured rat tooth bud cells. Histological and immunohistochemical studies of tissue engineered odontogenesis. Arch Histol Cytol. Varga G , Gerber G. Mesenchymal stem cells of dental origin as promising tools for neuroregeneration. Human dental pulp-derived stem cells promote locomotor recovery after complete transection of the rat spinal cord by multiple neuro-regenerative mechanisms.

J Clin Invest. Human dental pulp cells differentiate toward neuronal cells and promote neuroregeneration in adult organotypic hippocampal slices in vitro. Chrysin suppressed inflammatory responses and the inducible nitric oxide synthase pathway after spinal cord injury in rats. Potential roles of dental pulp stem cells in neural regeneration and repair. Stem Cells Int. Multifaceted neuro-regenerative activities of human dental pulp stem cells for functional recovery after spinal cord injury.

Neurosci Res. Analysis of the neuroregenerative activities of mesenchymal stem cells in functional recovery after rat spinal cord injury.

Methods Mol Biol. Potential of human dental stem cells in repairing the complete transection of rat spinal cord.

J Neural Eng. Taking a bite out of spinal cord injury: Do dental stem cells have the teeth for it? Cell Mol Life Sci. Chitosan scaffolds induce human dental pulp stem cells to neural differentiation: Potential roles for spinal cord injury therapy.

A simple and efficient method for generating nurr1-positive neuronal stem cells from human wisdom teeth tNSC and the potential of tNSC for stroke therapy. Human adult dental pulp stem cells enhance poststroke functional recovery through non-neural replacement mechanisms.

Stem Cells Transl Med. Concise review: Preclinical studies on human cell-based therapy in rodent ischemic stroke models: Where are we now after a decade?

Comparison of the effects of human dental pulp stem cells and human bone marrow-derived mesenchymal stem cells on ischemic human astrocytes in vitro. J Neurosci Res. Dauer W , Przedborski S. Parkinson's disease: Mechanisms and models. Effect of dental pulp stem cells in MPTP-induced old-aged mice model. Eur J Clin Invest.

Citron M. Alzheimer's disease: Strategies for disease modification. Nat Rev Drug Discov. Huang Y , Mucke L. Alzheimer mechanisms and therapeutic strategies. Dental pulp stem cells promote regeneration of damaged neuron cells on the cellular model of Alzheimer's disease. Cell Biol Int. Therapeutic potential of dental pulp stem cell secretome for Alzheimer's disease treatment: An in vitro study. Conditioned medium from the stem cells of human dental pulp improves cognitive function in a mouse model of Alzheimer's disease.

Behav Brain Res. Retinal stem cells. Methods Enzymol. Munemasa Y , Kitaoka Y. Autophagy in axonal degeneration in glaucomatous optic neuropathy. Prog Retin Eye Res. Intravitreally transplanted dental pulp stem cells promote neuroprotection and axon regeneration of retinal ganglion cells after optic nerve injury. Invest Ophthalmol Vis Sci. Mesenchymal stromal cell-mediated neuroprotection and functional preservation of retinal ganglion cells in a rodent model of glaucoma.

PLGA artificial nerve conduits with dental pulp cells promote facial nerve regeneration. Engineered neural tissue with Schwann cell differentiated human dental pulp stem cells: Potential for peripheral nerve repair? Immunomodulatory properties of dental tissue-derived mesenchymal stem cells. Oral Dis. Human dental pulp stem cells suppress alloantigen-induced immunity by stimulating T cells to release transforming growth factor beta.

J Endod. Transplantation of SHED prevents bone loss in the early phase of ovariectomy-induced osteoporosis. An in vivo model for monitoring trans-differentiation of bone marrow cells into functional hepatocytes.

J Biochem. Novel management of acute or secondary biliary liver conditions using hepatically differentiated human dental pulp cells. Clones of ectopic stem cells in the regeneration of muscle defects in vivo. Early transplantation of human immature dental pulp stem cells from baby teeth to golden retriever muscular dystrophy GRMD dogs: Local or systemic? J Transl Med. Differentiation of dental pulp stem cells into islet-like aggregates. Leake J , Templeton SK.

The Sunday Times. Stem Cells Dev. Fulltext Views 6, PDF downloads 9, Showing results from PubMed.



0コメント

  • 1000 / 1000