Skip to main content. Ketamine for Adult Depression Study Print record. Trial Information. Approved Trial summary The aim of this study is to determine if a course of ketamine is an effective therapy for depression.
The study will also determine if repeated ketamine doses: 1 are safe, tolerable and feasible in outpatient settings; 2 provide sustained antidepressant benefits; 3 improve anxiety, suicidal ideation and health related quality of life; 4 are a cost effective treatment. The study is a randomised controlled trial. Participants will be randomised to receive repeated doses of ketamine or a comparator treatment.
Many depression sufferers will avoid depression treatment due to social stigma surrounding depression, which may lead to further depression symptoms and more serious depression complications in the future.
Some depression clinical trials may require depression patients to meet depression screening criteria. Depression screening is a depression test that determines the likelihood of depression symptoms being present. Depression clinical trials can be extremely beneficial for depression sufferers as they involve a combination of different depression treatments in one depression study, which may increase the possibility of finding an effective depression treatment.
Depression clinical trials will also include some form of depression testing which depression researchers will use to monitor depression symptoms and depression triggers throughout the depression study. Clinical trials are a great way to help further research regarding depression, and also to get access to care from experts in the field. Depression clinical trials are mostly carried out to determine the safety and efficacy of new medications and procedures, and they are led by a research team.
A patient can obtain life-changing treatments through a clinical trial; however, it is important to note that if the patient wishes to leave the trial for any reason, they may do so at any point during the research. What Is Depression? D epression is a fairly common mood disorder; you have probably met someone suffering from depression at some point in your life, or you might have even suffered from it yourself.
Some of these symptoms are:. Feeling sad or depressed Fatigue Lack of concentration, impaired memory Sleeping less or more than usual Irritability.
Weight loss or weight gain Feelings of guilt Loss of interest in activities you used to enjoy Thoughts about death or suicide; suicide attempts. Match to Depression Clinical Trials Access to cutting-edge treatments Latest clinical trials Find trials in your area. Start Matching. What Causes Depression? Biochemistry The disease might be caused or worsened by an imbalance of certain chemicals in the brain. Comorbidities Suffering from other illnesses can trigger depression. Hormonal Changes For women, depression can be related to hormonal changes, especially after childbirth or during menopause.
Environment Being exposed to stressful situations, violence, major life events, amongst others, can trigger depression. How is Depression Diagnosed? How is Depression Treated? Antidepressants include: Selective serotonin reuptake inhibitors SSRIs : citalopram, escitalopram, fluoxetine, sertraline, paroxetine, vortioxetine approved in amongst others. Tricyclic antidepressants TCAs : amitriptyline, clomipramine, doxepin, nortriptyline, amongst others.
Monoamine oxidase inhibitors MAOIs : isocarboxazid, phenelzine, tranylcypromine, and selegiline amongst others. Prevention: Study that assesses an intervention to prevent a condition. Diagnosis: Study that assesses an intervention to diagnose a condition. Phase of Trial Phase 1: the first tests of a treatment in humans that aim to test safety and the best drug dose.
Phase 2: aim to see how well the new treatment works and to monitor for side effects.
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